The present study is to investigate the antioxidant activity of ethanol extract of flowers of Spathodea campanulata through nitric oxide radical, superoxide radical scavenging assay and phosphomolybdonum method. Ethanol extract of flowers of Spathodea campanulata showed significant dose dependent antioxidant activity, with a direct relationship between activity and concentration of extract. The extract showed an important free radical scavenging activity towards the nitric oxide and superoxide radicals, with IC50 values of 175 and 246 µg/mL respectively. Total antioxidant capacity was found to be 50 and 500 µg/mL of Spathodea campanulata extract and was equivalent to 8.42 and 148.8 µg/mL of α-Tocopherol. At 500µg/mL nitric oxide and superoxide radical scavenging assay showed maximum inhibition of 74 and 79% respectively. The extract showed significant activity in all assay when compared to the standard antioxidants. These results clearly indicate that the Spathodea campanulata flowers is a potential antioxidant and nitric oxide and superoxide radicals scavenging activity.
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